PT  - JOURNAL ARTICLE
AU  - Murugappan, A.
AU  - Coplin, W. M.
AU  - Al-Sadat, A. N.
AU  - McAllen, K. J.
AU  - Schwamm, L. H.
AU  - Wechsler, L. R.
AU  - Kidwell, C. S.
AU  - Saver, J. L.
AU  - Starkman, S.
AU  - Gobin, Y. P.
AU  - Duckwiler, G.
AU  - Krueger, M.
AU  - Rordorf, G.
AU  - Broderick, J. P.
AU  - Tietjen, G. E.
AU  - Levine, S. R.
TI  - Thrombolytic therapy of acute ischemic stroke during pregnancy
AID  - 10.1212/01.wnl.0000201272.90216.15
DP  - 2006 Mar 14
TA  - Neurology
PG  - 768--770
VI  - 66
IP  - 5
4099  - http://n.neurology.org/content/66/5/768.short
4100  - http://n.neurology.org/content/66/5/768.full
SO  - Neurology2006 Mar 14; 66
AB  - The authors report eight pregnant women with acute ischemic stroke treated with thrombolysis (rt-PA [recombinant human tissue plasminogen activator] or urokinase). Seven women recovered. Two extracranial and two asymptomatic intracranial hemorrhages complicated treatment; one woman died of arterial dissection complicating angiography. Three patients had therapeutic abortions, two fetuses were miscarried, and two babies were delivered healthy. Although pregnant women may be treated safely with thrombolytics, risks and benefits to mother and fetus must be carefully weighed.