RT Journal Article
SR Electronic
T1 Thrombolytic therapy of acute ischemic stroke during pregnancy
JF Neurology
JO Neurology
FD Lippincott Williams & Wilkins
SP 768
OP 770
DO 10.1212/01.wnl.0000201272.90216.15
VO 66
IS 5
A1 Murugappan, A.
A1 Coplin, W. M.
A1 Al-Sadat, A. N.
A1 McAllen, K. J.
A1 Schwamm, L. H.
A1 Wechsler, L. R.
A1 Kidwell, C. S.
A1 Saver, J. L.
A1 Starkman, S.
A1 Gobin, Y. P.
A1 Duckwiler, G.
A1 Krueger, M.
A1 Rordorf, G.
A1 Broderick, J. P.
A1 Tietjen, G. E.
A1 Levine, S. R.
YR 2006
UL http://n.neurology.org/content/66/5/768.abstract
AB The authors report eight pregnant women with acute ischemic stroke treated with thrombolysis (rt-PA [recombinant human tissue plasminogen activator] or urokinase). Seven women recovered. Two extracranial and two asymptomatic intracranial hemorrhages complicated treatment; one woman died of arterial dissection complicating angiography. Three patients had therapeutic abortions, two fetuses were miscarried, and two babies were delivered healthy. Although pregnant women may be treated safely with thrombolytics, risks and benefits to mother and fetus must be carefully weighed.