PT  - JOURNAL ARTICLE
AU  - Blumenthal, D. T.
AU  - Salzman, K. L.
AU  - Digre, K. B.
AU  - Jensen, R. L.
AU  - Dunson, W. A.
AU  - Dalmau, J.
TI  - Early pathologic findings and long-term improvement in anti-Ma2–associated encephalitis
AID  - 10.1212/01.wnl.0000223647.83708.20
DP  - 2006 Jul 11
TA  - Neurology
PG  - 146--149
VI  - 67
IP  - 1
4099  - http://n.neurology.org/content/67/1/146.short
4100  - http://n.neurology.org/content/67/1/146.full
SO  - Neurology2006 Jul 11; 67
AB  - A 67-year-old man sequentially developed anti-Ma2–associated paraneoplastic encephalitis (PNE) and contralateral herpes simplex encephalitis (HSE). Brain biopsy 1 month before HSE revealed extensive infiltrates of T cells, B cells, and plasma cells. Most T cells expressed the cytotoxic granule–associated protein TIA-1 and the membranolytic protein granzyme-B. Although recovery was thought to be unlikely, treatment of the PNE with corticosteroids and resection of the associated lung cancer resulted in dramatic improvement for 21 months.