RT Journal Article
SR Electronic
T1 Early pathologic findings and long-term improvement in anti-Ma2–associated encephalitis
JF Neurology
JO Neurology
FD Lippincott Williams & Wilkins
SP 146
OP 149
DO 10.1212/01.wnl.0000223647.83708.20
VO 67
IS 1
A1 Blumenthal, D. T.
A1 Salzman, K. L.
A1 Digre, K. B.
A1 Jensen, R. L.
A1 Dunson, W. A.
A1 Dalmau, J.
YR 2006
UL http://n.neurology.org/content/67/1/146.abstract
AB A 67-year-old man sequentially developed anti-Ma2–associated paraneoplastic encephalitis (PNE) and contralateral herpes simplex encephalitis (HSE). Brain biopsy 1 month before HSE revealed extensive infiltrates of T cells, B cells, and plasma cells. Most T cells expressed the cytotoxic granule–associated protein TIA-1 and the membranolytic protein granzyme-B. Although recovery was thought to be unlikely, treatment of the PNE with corticosteroids and resection of the associated lung cancer resulted in dramatic improvement for 21 months.