RT Journal Article
SR Electronic
T1 Associations between white matter lesions, cerebrovascular risk factors, and low CSF Aβ42
JF Neurology
JO Neurology
FD Lippincott Williams & Wilkins
SP 830
OP 833
DO 10.1212/01.wnl.0000234030.77831.5a
VO 67
IS 5
A1 Stenset, V.
A1 Johnsen, L.
A1 Kocot, D.
A1 Negaard, A.
A1 Skinningsrud, A.
A1 Gulbrandsen, P.
A1 Wallin, A.
A1 Fladby, T.
YR 2006
UL http://n.neurology.org/content/67/5/830.abstract
AB Objective: To analyze a putative relationship between white matter lesions (WMLs), risk factors for WMLs, and Alzheimer disease (AD) as measured with the surrogate marker CSF Aβ42. Methods: The authors analyzed effects of acquired risk factors for cerebrovascular disease and WMLs on AD as measured with an intermediate marker, CSF Aβ42. A total of 127 consecutive patients with subjective memory impairment (mean age 66 years; 57 women) investigated at a university-based memory clinic had brain MRI scans. WMLs were rated on a 12-point scale with a semiquantitative procedure. They used path analysis with established and possible risk factors for WMLs and for reduced CSF Aβ42 (age, hypertension, hyperhomocysteinemia, hypercholesterolemia, APOE-ε4) as variables. Results: The WML score was 1.5 points higher (p < 0.05) in hypertensive than in nonhypertensive patients and 1.9 points higher (p < 0.05) in patients with hyperhomocysteinemia than in those with normal homocysteine levels. Hypercholesterolemia increased the probability of low CSF Aβ42 levels by 0.2 (p < 0.05). For each point increase in WML score, the probability of low CSF Aβ42 levels increased by 0.03 (p < 0.05). APOE-ε4 was associated with reduced CSF Aβ42 (p < 0.01). Conclusion: Both hypercholesterolemia and white matter lesions may contribute to low CSF Aβ42 by independent mechanisms.