PT  - JOURNAL ARTICLE
AU  - Carpentier, C.
AU  - Laigle-Donadey, F.
AU  - Marie, Y.
AU  - Auger, N.
AU  - Benouaich-Amiel, A.
AU  - Lejeune, J.
AU  - Kaloshi, G.
AU  - Delattre, J. -Y.
AU  - Thillet, J.
AU  - Sanson, M.
TI  - Polymorphism in Sp1 recognition site of the <em>EGF</em> receptor gene promoter and risk of glioblastoma
AID  - 10.1212/01.wnl.0000229927.12007.37
DP  - 2006 Sep 12
TA  - Neurology
PG  - 872--874
VI  - 67
IP  - 5
4099  - http://n.neurology.org/content/67/5/872.short
4100  - http://n.neurology.org/content/67/5/872.full
SO  - Neurology2006 Sep 12; 67
AB  - We investigated two polymorphisms of the epidermal growth factor receptor promoter as potential risk factors and prognostic markers for glioblastoma. The −216T allele (which results in a 30% higher activity) was more frequent in the patients compared with the control population (224/376 = 59.6% vs 165/352 = 46.8%; p = 0.0006) corresponding to an odd ratio of 1.67 (1.24; 2.25). A modest difference in median survival was also associated with the TT genotype.