RT Journal Article
SR Electronic
T1 Polymorphism in Sp1 recognition site of the <em>EGF</em> receptor gene promoter and risk of glioblastoma
JF Neurology
JO Neurology
FD Lippincott Williams &amp; Wilkins
SP 872
OP 874
DO 10.1212/01.wnl.0000229927.12007.37
VO 67
IS 5
A1 Carpentier, C.
A1 Laigle-Donadey, F.
A1 Marie, Y.
A1 Auger, N.
A1 Benouaich-Amiel, A.
A1 Lejeune, J.
A1 Kaloshi, G.
A1 Delattre, J. -Y.
A1 Thillet, J.
A1 Sanson, M.
YR 2006
UL http://n.neurology.org/content/67/5/872.abstract
AB We investigated two polymorphisms of the epidermal growth factor receptor promoter as potential risk factors and prognostic markers for glioblastoma. The −216T allele (which results in a 30% higher activity) was more frequent in the patients compared with the control population (224/376 = 59.6% vs 165/352 = 46.8%; p = 0.0006) corresponding to an odd ratio of 1.67 (1.24; 2.25). A modest difference in median survival was also associated with the TT genotype.