PT  - JOURNAL ARTICLE
AU  - Deleu, D.
AU  - Jacob, P.
AU  - Chand, P.
AU  - Sarre, S.
AU  - Colwell, A.
TI  - Effects of caffeine on levodopa pharmacokinetics and pharmacodynamics in Parkinson disease
AID  - 10.1212/01.wnl.0000233916.57415.9d
DP  - 2006 Sep 12
TA  - Neurology
PG  - 897--899
VI  - 67
IP  - 5
4099  - http://n.neurology.org/content/67/5/897.short
4100  - http://n.neurology.org/content/67/5/897.full
SO  - Neurology2006 Sep 12; 67
AB  - The authors studied the acute effect of caffeine on the levodopa pharmacokinetics and pharmacodynamics in 12 patients with idiopathic Parkinson disease. This double-blind, randomized, crossover study revealed that caffeine shortened the maximal plasma concentration of levodopa, decreased the latency to levodopa walking and tapping motor response, and increased the magnitude of walking response. Caffeine administered before levodopa may improve its pharmacokinetics in some parkinsonian patients.