PT  - JOURNAL ARTICLE
AU  - Sprenger, A.
AU  - Rambold, H.
AU  - Sander, T.
AU  - Marti, S.
AU  - Weber, K.
AU  - Straumann, D.
AU  - Helmchen, C.
TI  - Treatment of the gravity dependence of downbeat nystagmus with 3,4-diaminopyridine
AID  - 10.1212/01.wnl.0000233829.76150.6b
DP  - 2006 Sep 12
TA  - Neurology
PG  - 905--907
VI  - 67
IP  - 5
4099  - http://n.neurology.org/content/67/5/905.short
4100  - http://n.neurology.org/content/67/5/905.full
SO  - Neurology2006 Sep 12; 67
AB  - The authors examined the effect of 3,4-diaminopyridine (DAP) on the gravity-dependent (GD) vertical ocular drift component of downbeat nystagmus in 11 patients with idiopathic cerebellar ataxia. With the head tilted downward (45°), DAP reduced slow phase velocity (SPV) in 7 of 11 patients by 36%. Its efficacy correlated with the GD modulation. DAP minimizes the gravity-independent velocity bias and may improve deficient inhibitory cerebellar control on overacting otolith–ocular reflexes.