RT Journal Article
SR Electronic
T1 Treatment of the gravity dependence of downbeat nystagmus with 3,4-diaminopyridine
JF Neurology
JO Neurology
FD Lippincott Williams & Wilkins
SP 905
OP 907
DO 10.1212/01.wnl.0000233829.76150.6b
VO 67
IS 5
A1 Sprenger, A.
A1 Rambold, H.
A1 Sander, T.
A1 Marti, S.
A1 Weber, K.
A1 Straumann, D.
A1 Helmchen, C.
YR 2006
UL http://n.neurology.org/content/67/5/905.abstract
AB The authors examined the effect of 3,4-diaminopyridine (DAP) on the gravity-dependent (GD) vertical ocular drift component of downbeat nystagmus in 11 patients with idiopathic cerebellar ataxia. With the head tilted downward (45°), DAP reduced slow phase velocity (SPV) in 7 of 11 patients by 36%. Its efficacy correlated with the GD modulation. DAP minimizes the gravity-independent velocity bias and may improve deficient inhibitory cerebellar control on overacting otolith–ocular reflexes.