PT  - JOURNAL ARTICLE
AU  - Lin, P. I.
AU  - Martin, E. R.
AU  - Bronson, P. G.
AU  - Browning-Large, C.
AU  - Small, G. W.
AU  - Schmechel, D. E.
AU  - Welsh-Bohmer, K. A.
AU  - Haines, J. L.
AU  - Gilbert, J. R.
AU  - Pericak-Vance, M. A.
TI  - Exploring the association of glyceraldehyde-3-phosphate dehydrogenase gene and Alzheimer disease
AID  - 10.1212/01.wnl.0000223438.90113.4e
DP  - 2006 Jul 11
TA  - Neurology
PG  - 64--68
VI  - 67
IP  - 1
4099  - http://n.neurology.org/content/67/1/64.short
4100  - http://n.neurology.org/content/67/1/64.full
SO  - Neurology2006 Jul 11; 67
AB  - Background: Previous linkage studies have shown that chromosome 12 harbors susceptibility genes for late-onset Alzheimer disease (LOAD). However, association studies of several candidate genes on this chromosome region have produced ambiguous results. A recent study reported the association between the glyceraldehyde-3-phosphate dehydrogenase (GAPD) gene on chromosome 12p and the risk of LOAD. Methods: The authors conducted family-based and case-control association studies in two independent LOAD data sets on 12 single-nucleotide polymorphisms (SNPs) in the GAPD gene and its paralogs. Results: No association was found of the GAPD gene with LOAD in the family-based data set, but marginal evidence of association was seen in the later-onset subgroup when age at onset was stratified. The SNP rs2029721 in one GAPD pseudogene was also found to be associated with risk for LOAD in the unrelated case-control data set (p = 0.003). Conclusions: The GAPD gene and its pseudogene may play a role in the development of late-onset Alzheimer disease. However, the effect, if any, is likely to be limited.