RT Journal Article
SR Electronic
T1 Exploring the association of glyceraldehyde-3-phosphate dehydrogenase gene and Alzheimer disease
JF Neurology
JO Neurology
FD Lippincott Williams & Wilkins
SP 64
OP 68
DO 10.1212/01.wnl.0000223438.90113.4e
VO 67
IS 1
A1 Lin, P. I.
A1 Martin, E. R.
A1 Bronson, P. G.
A1 Browning-Large, C.
A1 Small, G. W.
A1 Schmechel, D. E.
A1 Welsh-Bohmer, K. A.
A1 Haines, J. L.
A1 Gilbert, J. R.
A1 Pericak-Vance, M. A.
YR 2006
UL http://n.neurology.org/content/67/1/64.abstract
AB Background: Previous linkage studies have shown that chromosome 12 harbors susceptibility genes for late-onset Alzheimer disease (LOAD). However, association studies of several candidate genes on this chromosome region have produced ambiguous results. A recent study reported the association between the glyceraldehyde-3-phosphate dehydrogenase (GAPD) gene on chromosome 12p and the risk of LOAD. Methods: The authors conducted family-based and case-control association studies in two independent LOAD data sets on 12 single-nucleotide polymorphisms (SNPs) in the GAPD gene and its paralogs. Results: No association was found of the GAPD gene with LOAD in the family-based data set, but marginal evidence of association was seen in the later-onset subgroup when age at onset was stratified. The SNP rs2029721 in one GAPD pseudogene was also found to be associated with risk for LOAD in the unrelated case-control data set (p = 0.003). Conclusions: The GAPD gene and its pseudogene may play a role in the development of late-onset Alzheimer disease. However, the effect, if any, is likely to be limited.