PT - JOURNAL ARTICLE AU - M. E. Bigal AU - S. Ashina AU - R. Burstein AU - M. L. Reed AU - D. Buse AU - D. Serrano AU - R. B. Lipton ED - , TI - Prevalence and characteristics of allodynia in headache sufferers AID - 10.1212/01.wnl.0000310645.31020.b1 DP - 2008 Apr 22 TA - Neurology PG - 1525--1533 VI - 70 IP - 17 4099 - http://n.neurology.org/content/70/17/1525.short 4100 - http://n.neurology.org/content/70/17/1525.full SO - Neurology2008 Apr 22; 70 AB - Objective: The authors estimated the prevalence and severity of cutaneous allodynia (CA) in individuals with primary headaches from the general population. Methods: We mailed questionnaires to a random sample of 24,000 headache sufferers previously identified from the population. The questionnaire included the validated Allodynia Symptom Checklist (ASC) as well as measures of headache features, disability, and comorbidities. We modeled allodynia as an outcome using headache diagnosis, frequency and severity of headaches, and disability as predictor variables in logistic regression. Covariates included demographic variables, comorbidities, use of preventive medication, and use of opioids. Results: Complete surveys were returned by 16,573 individuals. The prevalence of CA of any severity (ASC score ≥3) varied with headache type. Prevalence was significantly higher in transformed migraine (TM, 68.3%) than in episodic migraine (63.2%, p < 0.01) and significantly elevated in both of these groups compared with probable migraine (42.6%), other chronic daily headaches (36.8%), and severe episodic tension-type headache (36.7%). The prevalence of severe CA (ASC score ≥9) was also highest in TM (28.5%) followed by migraine (20.4%), probable migraine (12.3%), other chronic daily headaches (6.2%), and severe episodic tension-type headache (5.1%). In the migraine and TM groups, prevalence of CA was higher in women and increased with disability score. Among migraineurs, CA increased with headache frequency and body mass index. In all groups, ASC scores were higher in individuals with major depression. Conclusions: Cutaneous allodynia (CA) is more common and more severe in transformed migraine and migraine than in other primary headaches. Among migraineurs, CA is associated with female sex, headache frequency, increased body mass index, disability, and depression. AMPP=American Migraine Prevalence and Prevention; ASC=Allodynia Symptom Checklist; CA=cutaneous allodynia; CDH=chronic daily headaches; MIDAS=Migraine Disability Assessment; O-CDH=other chronic daily headaches; PM=probable migraine; PR=prevalence ratio; QST=quantitative sensory testing; S-ETTH=severe episodic tension-type headache; TM=transformed migraine.