RT Journal Article SR Electronic T1 Anatomical correlate of positive spontaneous visual phenomena JF Neurology JO Neurology FD Lippincott Williams & Wilkins SP 218 OP 222 DO 10.1212/WNL.0b013e3181cb3e64 VO 74 IS 3 A1 Baier, B. A1 de Haan, B. A1 Mueller, N. A1 Thoemke, F. A1 Birklein, F. A1 Dieterich, M. A1 Karnath, H. -O. YR 2010 UL http://n.neurology.org/content/74/3/218.abstract AB Objectives: Visual phenomena such as phosphenes, photopsias, or complex visual hallucinations occur in patients with lesions affecting the occipital, parietal, or temporal lobe. Whether these phenomena are provoked by lesions in specific anatomical regions is still uncertain. To determine which brain regions might be involved in such visual phenomena, we used new brain imaging and lesion analysis tools that allow a direct comparison with control patients. Methods: Visual phenomena were investigated in a total of 23 patients with acute infarctions along the visual pathways (6 patients with left-sided and 17 patients with right-sided lesions). Results: Ten of these 23 patients (43%) reported positive spontaneous visual phenomena (PSVP). Nine of the 10 patients (90%) with PSVP reported phosphenes; only 3 of the 10 (30%) reported photopsias. Statistical voxelwise lesion-behavior mapping revealed that the areas specifically related to PSVP are V1, V2, and the optic radiation. Conclusions: Disinhibition of earlier visual areas after lesions of the visual cortex and its afferent fibers seems to be the crucial mechanism in the genesis of visual phenomena in acute stroke patients. DWI=diffusion-weighted imaging; FLAIR=fluid-attenuated inversion recovery; FOV=field of view; HAN=hemianopic anosognosia; MCA=middle cerebral artery; MNI=Montreal Neurological Institute; PCA=posterior cerebral artery; PSVP=positive spontaneous visual phenomena; TE=echo time; TR=repetition time; VLBM=voxelwise lesion-behavior mapping.