RT Journal Article
SR Electronic
T1 Obesity phenotypes in midlife and cognition in early old age
JF Neurology
JO Neurology
FD Lippincott Williams & Wilkins
SP 755
OP 762
DO 10.1212/WNL.0b013e3182661f63
VO 79
IS 8
A1 Singh-Manoux, Archana
A1 Czernichow, Sébastien
A1 Elbaz, Alexis
A1 Dugravot, Aline
A1 Sabia, Séverine
A1 Hagger-Johnson, Gareth
A1 Kaffashian, Sara
A1 Zins, Marie
A1 Brunner, Eric J.
A1 Nabi, Hermann
A1 Kivimäki, Mika
YR 2012
UL http://n.neurology.org/content/79/8/755.abstract
AB Objective: To examine the association of body mass index (BMI) and metabolic status with cognitive function and decline. Methods: A total of 6,401 adults (71.2% men), aged 39–63 years in 1991–1993, provided data on BMI (normal weight 18.5–24.9 kg/m2, overweight 25–29.9 kg/m2; and obese ≥30 kg/m2) and metabolic status (abnormality defined as 2 or more of 1) triglycerides ≥1.69 mmol/L or lipid-lowering drugs, 2) systolic blood pressure ≥130 mm Hg, diastolic blood pressure ≥85 mm Hg, or antihypertensive drugs, 3) glucose ≥5.6 mmol/L or medications for diabetes, and 4) high-density lipoprotein cholesterol <1.04 mmol/L for men and <1.29 mmol/L for women). Four cognitive tests (memory, reasoning, semantic, and phonemic fluency) were administered in 1997–1999, 2002–2004, and 2007–2009, standardized to z scores, and averaged to yield a global score. Results: Of the participants, 31.0% had metabolic abnormalities, 52.7% were normal weight, 38.2% were overweight, and 9.1% were obese. Among the obese, the global cognitive score at baseline (p = 0.82) and decline (p = 0.19) over 10 years was similar in the metabolically normal and abnormal groups. In the metabolically normal group, the 10-year decline in the global cognitive score was similar (p for trend = 0.36) in the normal weight (−0.40; 95% confidence interval [CI] −0.42 to −0.38), overweight (−0.42; 95% CI −0.45 to −0.39), and obese (−0.42; 95% CI −0.50 to −0.34) groups. However, in the metabolically abnormal group, the decline on the global score was faster among obese (−0.49; 95% CI −0.55 to −0.42) than among normal weight individuals (−0.42; 95% CI −0.50 to −0.34), (p = 0.03). Conclusions: In these analyses the fastest cognitive decline was observed in those with both obesity and metabolic abnormality. BMI=body mass index; HDL=high-density lipoprotein; MHO=metabolically healthy obesity