PT  - JOURNAL ARTICLE
AU  - Thaler, Avner
AU  - Mirelman, Anat
AU  - Gurevich, Tanya
AU  - Simon, Ely
AU  - Orr-Urtreger, Avi
AU  - Marder, Karen
AU  - Bressman, Susan
AU  - Giladi, Nir
TI  - Lower cognitive performance in healthy G2019S <em>LRRK2</em> mutation carriers
AID  - 10.1212/WNL.0b013e3182684646
DP  - 2012 Sep 04
TA  - Neurology
PG  - 1027--1032
VI  - 79
IP  - 10
4099  - http://n.neurology.org/content/79/10/1027.short
4100  - http://n.neurology.org/content/79/10/1027.full
SO  - Neurology2012 Sep 04; 79
AB  - Objective: To assess cognitive abilities of healthy first-degree relatives of Ashkenazi patients with Parkinson disease (PD), carriers of the G2019S mutation in the LRRK2 gene. Methods: In this observational study, 60 consecutive healthy first-degree relatives (aged 50.9 ± 6.2 years; 48% male; 30 G2019S carriers) were assessed using a computerized cognitive program, the Montreal Cognitive Assessment questionnaire, the Unified Parkinson's Disease Rating Scale Part III, and the Geriatric Depression Scale. Results: G2019S carriers scored significantly lower on the computerized executive function index (p = 0.04) and on specific executive function tasks (Stroop test, p = 0.007). Conclusion: Carrying the LRRK2 G2019S mutation was associated with lower executive performance in a population at risk for PD. AJ=Ashkenazi Jewish; EF=executive function; GDS=Geriatric Depression Scale; MoCA=Montreal Cognitive Assessment test; PD=Parkinson disease; RT=reaction time; UPDRS=Unified Parkinson's Disease Rating Scale