PT - JOURNAL ARTICLE AU - Cheng-Ching, Esteban AU - Samaniego, Edgar A. AU - Naravetla, Bharath Reddy AU - Zaidat, Osama O. AU - Hussain, Muhammad Shazam TI - Update on pharmacology of antiplatelets, anticoagulants, and thrombolytics AID - 10.1212/WNL.0b013e3182695871 DP - 2012 Sep 25 TA - Neurology PG - S68--S76 VI - 79 IP - 13 Supplement 1 4099 - http://n.neurology.org/content/79/13_Supplement_1/S68.short 4100 - http://n.neurology.org/content/79/13_Supplement_1/S68.full SO - Neurology2012 Sep 25; 79 AB - Understanding of the pharmacology of thrombolytics, anticoagulants, and antiplatelets is critical to performing safe and effective endovascular therapy for acute ischemic therapy. This is a basic review of the clinical pharmacologic data on the anticoagulants, antiplatelets, and fibrinolytic agents most commonly used in the treatment of stroke and in the neurointerventional suite. CYP=cytochrome P450; FDA=US Food and Drug Administration; HIT=heparin-induced thrombocytopenia; LMWH=low-molecular-weight heparin; Pro-UK=prourokinase; rtPA=recombinant tissue plasminogen activator; tPA=tissue plasminogen activator; UFH=unfractionated heparin; VTE=venous thromboembolism