RT Journal Article
SR Electronic
T1 Alcohol use and risk of intracerebral hemorrhage
JF Neurology
JO Neurology
FD Lippincott Williams & Wilkins
SP 2043
OP 2051
DO 10.1212/WNL.0000000000003952
VO 88
IS 21
A1 Chen, Ching-Jen
A1 Brown, W. Mark
A1 Moomaw, Charles J.
A1 Langefeld, Carl D.
A1 Osborne, Jennifer
A1 Worrall, Bradford B.
A1 Woo, Daniel
A1 Koch, Sebastian
A1 ,
YR 2017
UL http://n.neurology.org/content/88/21/2043.abstract
AB Objective: To analyze the dose–risk relationship for alcohol consumption and intracerebral hemorrhage (ICH) in the Ethnic/Racial Variations of Intracerebral Hemorrhage (ERICH) study.Methods: ERICH is a multicenter, prospective, case-control study, designed to recruit 1,000 non-Hispanic white patients, 1,000 non-Hispanic black patients, and 1,000 Hispanic patients with ICH. Cases were matched 1:1 to ICH-free controls by age, sex, race/ethnicity, and geographic area. Comprehensive interviews included questions regarding alcohol consumption. Patterns of alcohol consumption were categorized as none, rare (<1 drink per month), moderate (≥1 drink per month and ≤2 drinks per day), intermediate (>2 drinks per day and <5 drinks per day), and heavy (≥5 drinks per day). ICH risk was calculated using the no-alcohol use category as the reference group.Results: Multivariable analyses demonstrated an ordinal trend for alcohol consumption: rare (odds ratio [OR] 0.57, p < 0.0001), moderate (OR 0.65, p < 0.0001), intermediate (OR 0.82, p = 0.2666), and heavy alcohol consumption (OR 1.77, p = 0.0003). Subgroup analyses demonstrated an association of rare and moderate alcohol consumption with decreased risk of both lobar and nonlobar ICH. Heavy alcohol consumption demonstrated a strong association with increased nonlobar ICH risk (OR 2.04, p = 0.0003). Heavy alcohol consumption was associated with significant increase in nonlobar ICH risk in black (OR 2.34, p = 0.0140) and Hispanic participants (OR 12.32, p < 0.0001). A similar association was not found in white participants.Conclusions: This study demonstrated potential protective effects of rare and moderate alcohol consumption on ICH risk. Heavy alcohol consumption was associated with increased ICH risk. Race/ethnicity was a significant factor in alcohol-associated ICH risk; heavy alcohol consumption in black and Hispanic participants poses significant nonlobar ICH risk.BMI=body mass index; BP=blood pressure; CAD=coronary artery disease; CI=confidence interval; DM=diabetes mellitus; ERICH=Ethnic/Racial Variations of Intracerebral Hemorrhage; HDL=high-density lipoprotein; ICH=intracerebral hemorrhage; INR=international normalized ratio; LDL=low-density lipoprotein; MI=myocardial infarction; mRS=modified Rankin Scale; OR=odds ratio; PT=prothrombin time; PTT=partial thromboplastin time; RR=relative risk