RT Journal Article
SR Electronic
T1 Treatment with statins and ischemic stroke severity
JF Neurology
JO Neurology
FD Lippincott Williams & Wilkins
SP 1800
OP 1805
DO 10.1212/WNL.0b013e3182918d38
VO 80
IS 19
A1 Martínez-Sánchez, Patricia
A1 Fuentes, Blanca
A1 Martínez-Martínez, Marta
A1 Ruiz-Ares, Gerardo
A1 Fernández-Travieso, Jorge
A1 Sanz-Cuesta, Borja Enrique
A1 Cuéllar-Gamboa, Lorena
A1 Díaz-Domínguez, Elena
A1 Díez-Tejedor, Exuperio
YR 2013
UL http://n.neurology.org/content/80/19/1800.abstract
AB Objective: To examine the effects of pretreatment with statins at high doses (40 mg of rosuvastatin or 80 mg of any other statin) and low to moderate doses (<40 mg of rosuvastatin or <80 mg of any other statin) on ischemic stroke (IS) severity in clinical practice.Methods: Observational study of IS admissions to our stroke unit over a 3-year period (2008–2010). Mild stroke severity was defined as NIH Stroke Scale score ≤5 on admission. Multivariable regression models and matched propensity score analyses were used to quantify the association of statin pretreatment at high and low to moderate doses with mild stroke severity.Results: Of the 969 IS patients, 23% were taking low to moderate doses and 4.1% were taking high doses of statins prior to the stroke. Statins were associated with lower NIHSS scores on admission (median [interquartile range] 4 [9] for nonstatin patients, 4 [9] for low to moderate doses of statins, and 2 [4] for high doses of statins; p = 0.010). After multivariable adjustment, pretreatment with statins was associated with a higher probability of mild stroke severity in the unmatched analysis (odds ratio [OR] = 1.637, 95% confidence interval [CI] 1.156–2.319 for the low to moderate doses and OR = 3.297, 95% CI 1.480–7.345 for the high doses of statins) as well as in the propensity score matched analysis (OR = 2.023, 95% CI 1.248–3.281 for the low to moderate doses and OR = 3.502, 95% CI 1.477–8.300 for the high doses of statins).Conclusion: Pretreatment with statins is associated with lower stroke severity, at high as well as at low to moderate doses.CI=confidence interval; mRS=modified Rankin Scale; NIHSS=NIH Stroke Scale; OR=odds ratio