RT Journal Article
SR Electronic
T1 Co-Morbidities of Neuropathic Postural Orthostatic Tachycardia Syndrome and of the Autonomic Neuropathies (P1.093)
JF Neurology
JO Neurology
FD Lippincott Williams & Wilkins
SP P1.093
VO 82
IS 10 Supplement
A1 Chemali, Kamal
A1 Mc Neeley, Kevin
YR 2014
UL http://n.neurology.org/content/82/10_Supplement/P1.093.abstract
AB Objective To compare the prevalence of common disorders in POTS with that of disorders associated with diseases of the ANS Background Postural Orthostatic Tachycardia Syndrome (POTS) includes a spectrum of symptoms, which are also present in generalized dysautonomias. A pathophysiological link of POTS to the Autonomic Nervous System (ANS) is therefore suspected. Comparing co-morbidities of both conditions could shed further light onto that link. Design/Methods We reviewed 74 patients with POTS and retrieved all their associated diagnoses, retaining the 11 most common. We repeated the same process with 109 patients diagnosed with autonomic neuropathy (AN) who did not meet criteria for POTS. Results Ten out of the 11 most common conditions associated with POTS were also associated with AN but to different degrees. Migraine was the most common co-morbidity in POTS (55%). Other common co-morbidities included Chronic Fatigue Syndrome (CFS), Fibromyalgia and Irritable Bowel Syndrome (IBS). In AN, the most common co-morbidities were hypertension (56%), hypercholesterolemia (46%), migraine (40%) and diabetes (30%). Conclusions 1. Common co-morbidities between POTS and AN could reflect a common pathophysiology and a predominant role of the ANS in POTS. 2. Hemodynamic and metabolic disorders are more prevalent in AN than in POTS, whereas condition like Fibromyalgia, CFS and IBS are more common in POTS, which suggests that POTS is a syndromic rather than a disease-based dysautonomia. 3. The high prevalence of disorders such as Fibromyalgia and CFS in both POTS and AN, may point to a role of the ANS in these conditions.Disclosure: Dr. Chemali has nothing to disclose. Dr. Mc Neeley has nothing to disclose.Monday, April 28 2014, 3:00 pm-6:30 pm