RT Journal Article
SR Electronic
T1 Late-onset Alzheimer disease genetic variants in posterior cortical atrophy and posterior AD
JF Neurology
JO Neurology
FD Lippincott Williams & Wilkins
SP 1455
OP 1462
DO 10.1212/WNL.0000000000000335
VO 82
IS 16
A1 Carrasquillo, Minerva M.
A1 Khan, Qurat ul Ain
A1 Murray, Melissa E.
A1 Krishnan, Siddharth
A1 Aakre, Jeremiah
A1 Pankratz, V. Shane
A1 Nguyen, Thuy
A1 Ma, Li
A1 Bisceglio, Gina
A1 Petersen, Ronald C.
A1 Younkin, Steven G.
A1 Dickson, Dennis W.
A1 Boeve, Bradley F.
A1 Graff-Radford, Neill R.
A1 Ertekin-Taner, Nilüfer
YR 2014
UL http://n.neurology.org/content/82/16/1455.abstract
AB Objective: To investigate association of genetic risk factors for late-onset Alzheimer disease (LOAD) with risk of posterior cortical atrophy (PCA), a syndrome of visual impairment with predominant Alzheimer disease (AD) pathology in posterior cortical regions, and with risk of “posterior AD” neuropathology.Methods: We assessed 81 participants with PCA diagnosed clinically and 54 with neuropathologic diagnosis of posterior AD vs 2,523 controls for association with 11 significant single nucleotide polymorphisms (SNPs) from published LOAD risk genome-wide association studies.Results: There was highly significant association with APOE ε4 and increased risk of PCA (p = 0.0003, odds ratio [OR] = 3.17) and posterior AD (p = 1.11 × 10−17, OR = 6.43). No other locus was significant after corrections for multiple testing, although rs11136000 near CLU (p = 0.019, OR = 0.60) and rs744373 near BIN1 (p = 0.025, OR = 1. 63) associated nominally significantly with posterior AD, and rs3851179 at the PICALM locus had significant association with PCA (p = 0.0003, OR = 2.84). ABCA7 locus SNP rs3764650, which was also tested under the recessive model because of Hardy-Weinberg disequilibrium, also had nominally significant association with PCA risk. The direction of association at APOE, CLU, and BIN1 loci was the same for participants with PCA and posterior AD. The effects for all SNPs, except rs3851179, were consistent with those for LOAD risk.Conclusions: We identified a significant effect for APOE and nominate CLU, BIN1, and ABCA7 as additional risk loci for PCA and posterior AD. Our findings suggest that at least some of the genetic risk factors for LOAD are shared with these atypical conditions and provide effect-size estimates for their future genetic studies.AD=Alzheimer disease; BA=Brodmann area; CI=confidence interval; GWAS=genome-wide association study; LOAD=late-onset Alzheimer disease; MAF=minor allele frequency; NFT=neurofibrillary tangle; OR=odds ratio; PCA=posterior cortical atrophy; SNP=single nucleotide polymorphism