RT Journal Article
SR Electronic
T1 ABO blood type, factor VIII, and incident cognitive impairment in the REGARDS cohort
JF Neurology
JO Neurology
FD Lippincott Williams & Wilkins
SP 1271
OP 1276
DO 10.1212/WNL.0000000000000844
VO 83
IS 14
A1 Kristine S. Alexander
A1 Neil A. Zakai
A1 Sarah Gillett
A1 Leslie A. McClure
A1 Virginia Wadley
A1 Fred Unverzagt
A1 Mary Cushman
YR 2014
UL http://n.neurology.org/content/83/14/1271.abstract
AB Objective: To assess the relationships among ABO group, factor VIII (FVIII), and incident cognitive impairment in a large, prospective cohort study of black and white adults in the United States using a nested case-control design.Methods: Incident cognitive impairment was defined using cognitive domain tests over a mean follow-up of 3.4 years. ABO blood group was measured by genotyping in a nested case-control sample of 495 cases with cognitive impairment and 587 controls.Results: Those with blood group AB and those with higher FVIII had an increased risk of cognitive impairment, adjusting for age, race, region, and sex (respective odds ratios 1.82, 95% confidence interval [CI] 1.15–2.90; and 1.24, 95% CI 1.10–1.38 for 40 IU/dL higher FVIII). Mean FVIII was higher in those with blood type AB (142 IU/dL; 95% CI 119–165) compared with O (104 IU/dL; 95% CI 101–107), and FVIII mediated 18% of the association between AB group and incident cognitive impairment (95% CI for mediation −30% to 68%).Conclusions: Blood group AB and higher FVIII were associated with increased incidence of cognitive impairment in this prospective study. The association of blood group AB with incident cognitive impairment was not significantly mediated by FVIII levels.CHD=coronary heart disease; CI=confidence interval; CVD=cardiovascular disease; FVIII=factor VIII; REGARDS=Reasons for Geographic and Racial Differences in Stroke; SNP=single nucleotide polymorphism; vWF=von Willebrand factor