PT  - JOURNAL ARTICLE
AU  - Verghese, Joe
AU  - Ayers, Emmeline
AU  - Barzilai, Nir
AU  - Bennett, David A.
AU  - Buchman, Aron S.
AU  - Holtzer, Roee
AU  - Katz, Mindy J.
AU  - Lipton, Richard B.
AU  - Wang, Cuiling
TI  - Motoric cognitive risk syndrome
AID  - 10.1212/WNL.0000000000001084
DP  - 2014 Dec 09
TA  - Neurology
PG  - 2278--2284
VI  - 83
IP  - 24
4099  - http://n.neurology.org/content/83/24/2278.short
4100  - http://n.neurology.org/content/83/24/2278.full
SO  - Neurology2014 Dec 09; 83
AB  - Objective: To report incidence and risk factors for motoric cognitive risk syndrome (MCR), a newly described predementia syndrome characterized by slow gait and cognitive complaints.Methods: We examined incidence rates of MCR in 3,128 adults aged 60 years and older, MCR- and dementia-free at baseline, participating in 4 US-based cohort studies. Hazard ratios (HRs) with 95% confidence intervals (CIs) for the association of modifiable risk factors with risk of MCR were computed using Cox models.Results: Over a median follow-up time of 3.2 years, 823 of the 3,128 participants met MCR criteria. The overall age- and sex-adjusted incidence of MCR was 65.2/1,000 person-years (95% CI: 53.3–77.1), and ranged from 50.8/1,000 person-years to 79.6/1,000 person-years in the individual cohorts. MCR incidence was higher with older age but there were no sex differences. In the pooled sample adjusted for age, sex, education, and cohort source, strokes (HR 1.42, 95% CI: 1.14–1.77), Parkinson disease (HR 2.52, 95% CI: 1.68–3.76), depressive symptoms (HR 1.65, 95% CI: 1.28–2.13), sedentariness (HR 1.76, 95% CI: 1.44–2.17), and obesity (HR 1.39, 95% CI: 1.17–1.65) predicted risk of incident MCR.Conclusions: The incidence of MCR is high in older adults. Identification of modifiable risk factors for MCR will improve identification of high-risk individuals and help develop interventions to prevent cognitive decline in aging.BIMC=Blessed Information-Memory-Concentration; CI=confidence interval; EAS=Einstein Aging Study; HR=hazard ratio; MAP=Memory and Aging Project; MCI=mild cognitive impairment; MCR=motoric cognitive risk syndrome; MMSE=Mini-Mental State Examination; ROS=Religious Orders Study