RT Journal Article
SR Electronic
T1 Predicting the risk of mild cognitive impairment in the Mayo Clinic Study of Aging
JF Neurology
JO Neurology
FD Lippincott Williams & Wilkins
SP 1433
OP 1442
DO 10.1212/WNL.0000000000001437
VO 84
IS 14
A1 V. Shane Pankratz
A1 Rosebud O. Roberts
A1 Michelle M. Mielke
A1 David S. Knopman
A1 Clifford R. Jack, Jr
A1 Yonas E. Geda
A1 Walter A. Rocca
A1 Ronald C. Petersen
YR 2015
UL http://n.neurology.org/content/84/14/1433.abstract
AB Objective: We sought to develop risk scores for the progression from cognitively normal (CN) to mild cognitive impairment (MCI).Methods: We recruited into a longitudinal cohort study a randomly selected, population-based sample of Olmsted County, MN, residents, aged 70 to 89 years on October 1, 2004. At baseline and subsequent visits, participants were evaluated for demographic, clinical, and neuropsychological measures, and were classified as CN, MCI, or dementia. Using baseline demographic and clinical variables in proportional hazards models, we derived scores that predicted the risk of progressing from CN to MCI. We evaluated the ability of these risk scores to classify participants for MCI risk.Results: Of 1,449 CN participants, 401 (27.7%) developed MCI. A basic model had a C statistic of 0.60 (0.58 for women, 0.62 for men); an augmented model resulted in a C statistic of 0.70 (0.69 for women, 0.71 for men). Both men and women in the highest vs lowest sex-specific quartiles of the augmented model's risk scores had an approximately 7-fold higher risk of developing MCI. Adding APOE ε4 carrier status improved the model (p = 0.002).Conclusions: We have developed MCI risk scores using variables easily assessable in the clinical setting and that may be useful in routine patient care. Because of variability among populations, validation in independent samples is required. These models may be useful in identifying patients who might benefit from more expensive or invasive diagnostic testing, and can inform clinical trial design. Inclusion of biomarkers or other risk factors may further enhance the models.CI=confidence interval; CN=cognitively normal; CDR=Clinical Dementia Rating; DSM-IV=Diagnostic and Statistical Manual of Mental Disorders (Fourth Edition); IQR=interquartile range; MCI=mild cognitive impairment; MCSA=Mayo Clinic Study of Aging; SE=standard error; STMS=Short Test of Mental Status; UPDRS=Unified Parkinson's Disease Rating Scale; WAIS-R=Wechsler Adult Intelligence Scale–Revised; WMS-R=Wechsler Memory Scale–Revised