RT Journal Article SR Electronic T1 Recurrence of reversible cerebral vasoconstriction syndrome JF Neurology JO Neurology FD Lippincott Williams & Wilkins SP 1552 OP 1558 DO 10.1212/WNL.0000000000001473 VO 84 IS 15 A1 Chen, Shih-Pin A1 Fuh, Jong-Ling A1 Lirng, Jiing-Feng A1 Wang, Yen-Feng A1 Wang, Shuu-Jiun YR 2015 UL http://n.neurology.org/content/84/15/1552.abstract AB Objective: We aimed to investigate whether reversible cerebral vasoconstriction syndrome (RCVS) could recur and to identify the potential predictors of recurrence in a large cohort of patients.Methods: This study followed a cohort of 210 patients with RCVS in a hospital-based headache center from 2000 to 2012. All patients were regularly followed up by telephone after remission for RCVS and were particularly asked to return to our hospital immediately if they developed new acute, severe (i.e., thunderclap-like) headaches. Sequential neuroimaging studies were used to determine whether the patients had recurrent RCVS.Results: One hundred sixty-eight patients were successfully followed. The response rate was 80.8%, and the mean follow-up period was 37.5 ± 24.4 (range 6–131) months. Eighteen patients (10.7%) returned to our hospital because of new thunderclap-like headaches, and 9 (5.4% of the total 168, and 50% of 18) were confirmed to have recurrent RCVS that occurred a mean 40.9 ± 27.2 (median 35, range 6–87) months after the initial bout. The incidence rate was 1.71 per 100 person-years (95% confidence interval 1.68–1.75). Having sexual activities as a trigger for thunderclap headaches (hazard ratio = 5.68, 95% confidence interval 1.11–29.15, p = 0.038) was an independent predictor of recurrent RCVS. None of the patients with recurrent RCVS developed cerebrovascular complications.Conclusions: Recurrent RCVS should be considered when patients with RCVS develop new thunderclap-like headaches. Having sexual activities as a trigger for RCVS is a potential predictor of recurrent RCVS.CI=confidence interval; ICHD-2=International Classification of Headache Disorders, second edition; ICHD-3-b=International Classification of Headache Disorders, third edition (beta version); LI=Lindegaard index; MRA=magnetic resonance angiography; RCVS=reversible cerebral vasoconstriction syndrome; TCCS=transcranial color-coded sonography; VMCA=flow velocity of middle cerebral artery