RT Journal Article
SR Electronic
T1 Healthy eating and reduced risk of cognitive decline
JF Neurology
JO Neurology
FD Lippincott Williams & Wilkins
SP 2258
OP 2265
DO 10.1212/WNL.0000000000001638
VO 84
IS 22
A1 Andrew Smyth
A1 Mahshid Dehghan
A1 Martin O'Donnell
A1 Craig Anderson
A1 Koon Teo
A1 Peggy Gao
A1 Peter Sleight
A1 Gilles Dagenais
A1 Jeffrey L. Probstfield
A1 Andrew Mente
A1 Salim Yusuf
YR 2015
UL http://n.neurology.org/content/84/22/2258.abstract
AB Objective: We sought to determine the association of dietary factors and risk of cognitive decline in a population at high risk of cardiovascular disease.Methods: Baseline dietary intake and measures of the Mini-Mental State Examination were recorded in 27,860 men and women who were enrolled in 2 international parallel trials of the ONTARGET (Ongoing Telmisartan Alone and in Combination with Ramipril Global Endpoint Trial) and TRANSCEND (Telmisartan Randomised Assessment Study in ACE Intolerant Subjects with Cardiovascular Disease) studies. We measured diet quality using the modified Alternative Healthy Eating Index. Cox proportional hazards regression was used to determine the association between diet quality and risk of ≥3-point decline in Mini-Mental State Examination score, and reported as hazard ratio with 95% confidence intervals with adjustment for covariates.Results: During 56 months of follow-up, 4,699 cases of cognitive decline occurred. We observed lower risk of cognitive decline among those in the healthiest dietary quintile of modified Alternative Healthy Eating Index compared with lowest quintile (hazard ratio 0.76, 95% confidence interval 0.66–0.86, Q5 vs Q1). Lower risk of cognitive decline was consistent regardless of baseline cognitive level.Conclusion: We found that higher diet quality was associated with a reduced risk of cognitive decline. Improved diet quality represents an important potential target for reducing the global burden of cognitive decline.BMI=body mass index; CHF=congestive heart failure; CI=confidence interval; CV=cardiovascular; FFQ=Food Frequency Questionnaire; HR=hazard ratio; mAHEI=modified Alternative Healthy Eating Index; MMSE=Mini-Mental State Examination; ONTARGET=Ongoing Telmisartan Alone and in Combination with Ramipril Global Endpoint Trial; TRANSCEND=Telmisartan Randomised Assessment Study in ACE Intolerant Subjects with Cardiovascular Disease