RT Journal Article SR Electronic T1 Cognitive activity relates to cognitive performance but not to Alzheimer disease biomarkers JF Neurology JO Neurology FD Lippincott Williams & Wilkins SP 48 OP 55 DO 10.1212/WNL.0000000000001704 VO 85 IS 1 A1 Gidicsin, Christopher M. A1 Maye, Jacqueline E. A1 Locascio, Joseph J. A1 Pepin, Lesley C. A1 Philiossaint, Marlie A1 Becker, J. Alex A1 Younger, Alayna P. A1 Dekhtyar, Maria A1 Schultz, Aaron P. A1 Amariglio, Rebecca E. A1 Marshall, Gad A. A1 Rentz, Dorene M. A1 Hedden, Trey A1 Sperling, Reisa A. A1 Johnson, Keith A. YR 2015 UL http://n.neurology.org/content/85/1/48.abstract AB Objective: We aimed to determine whether there was a relationship between lifestyle factors and Alzheimer disease biomarkers.Methods: In a cross-sectional study, we evaluated self-reported histories of recent and past cognitive activity, self-reported history of recent physical activity, and objective recent walking activity in 186 clinically normal individuals with mean age of 74 ± 6 years. Using backward elimination general linear models, we tested the hypotheses that greater cognitive or physical activity would be associated with lower Pittsburgh compound B–PET retention, greater 18F-fluorodeoxyglucose–PET metabolism, and larger hippocampal volume, as well as better cognitive performance on neuropsychological testing.Results: Linear regression demonstrated that history of greater cognitive activity was correlated with greater estimated IQ and education, as well as better neuropsychological testing performance. Self-reported recent physical activity was related to objective exercise monitoring. However, contrary to hypotheses, we did not find evidence of an association of Pittsburgh compound B retention, 18F-fluorodeoxyglucose uptake, or hippocampal volume with past or current levels of cognitive activity, or with current physical activity.Conclusions: We conclude that a history of lifelong cognitive activity may support better cognitive performance by a mechanism that is independent of brain β-amyloid burden, brain glucose metabolism, or hippocampal volume.Aβ=β-amyloid; AD=Alzheimer disease; AMNART=American version of the National Adult Reading Test; CA=cognitive activity; FDG=18F-fluorodeoxyglucose; FS=FreeSurfer; GLM=general linear model; mcPiB=mean cortical Pittsburgh compound B; MP-RAGE=magnetization-prepared rapid-acquisition gradient echo; PiB=Pittsburgh compound B; PrecFDG=precuneus 18F-fluorodeoxyglucose; RelHippoVol=relative hippocampal volume; ROI=region of interest; TPASelf=self-reported total physical activity; TWAPed=pedometer-measured total walking activity; WalkSelf=self-reported walking activity