RT Journal Article
SR Electronic
T1 Statin treatment reduces the risk of poststroke seizures
JF Neurology
JO Neurology
FD Lippincott Williams & Wilkins
SP 701
OP 707
DO 10.1212/WNL.0000000000001814
VO 85
IS 8
A1 Guo, Jiang
A1 Guo, Jian
A1 Li, Jinmei
A1 Zhou, Muke
A1 Qin, Fengqin
A1 Zhang, Shihong
A1 Wu, Bo
A1 He, Li
A1 Zhou, Dong
YR 2015
UL http://n.neurology.org/content/85/8/701.abstract
AB Objective: To examine the potential efficacy of statin treatment in reducing the risk of poststroke seizures.Methods: In this cohort study, patients with a first-ever ischemic stroke and no history of epilepsy before stroke were enrolled. After a mean follow-up period of 2.5 years, a follow-up assessment was performed to identify poststroke epilepsy. Logistic regression and Cox regression analyses were used to assess the relationship between statin use and poststroke early-onset seizures or poststroke epilepsy.Results: Of 1,832 enrolled patients, 63 (3.4%) patients had poststroke early-onset seizures and 91 (5.0%) patients had poststroke epilepsy. Statin use was associated with a lower risk of poststroke early-onset seizures (odds ratio [OR] 0.35, 95% confidence interval [CI] 0.20–0.60, p < 0.001), and this reduced risk was seen mainly in patients who used a statin only in the acute phase (OR 0.36, 95% CI 0.20–0.62, p < 0.001). No significant association was found between statin use and poststroke epilepsy (OR 0.81, 95% CI 0.52–1.26, p = 0.349). In 63 patients who presented with early-onset seizures, statin use was associated with reduced risk of poststroke epilepsy (OR 0.34, 95% CI 0.13–0.88, p = 0.026).Conclusions: Statin use, especially in the acute phase, may reduce the risk of poststroke early-onset seizures. In addition, statin treatment may prevent the progression of initial poststroke seizure-induced neurodegeneration into chronic epilepsy. Because of the observational nature of the study, more studies are needed to confirm the results.Classification of evidence: This study provides Class III evidence that in patients with a first-ever ischemic stroke, the early use of statins reduces the risk of early poststroke seizures.CI=confidence interval; ES=poststroke early-onset seizures; HDL-C=high-density lipoprotein cholesterol; NIHSS=NIH Stroke Scale; OR=odds ratio; PSE=poststroke epilepsy; TOAST=Trial of Org 10172 in Acute Stroke Treatment