PT  - JOURNAL ARTICLE
AU  - Kevin A. Kerber
AU  - William J. Meurer
AU  - Devin L. Brown
AU  - James F. Burke
AU  - Timothy P. Hofer
AU  - Alexander Tsodikov
AU  - Ellen G. Hoeffner
AU  - A.M. Fendrick
AU  - Eric E. Adelman
AU  - Lewis B. Morgenstern
TI  - Stroke risk stratification in acute dizziness presentations
AID  - 10.1212/WNL.0000000000002141
DP  - 2015 Nov 24
TA  - Neurology
PG  - 1869--1878
VI  - 85
IP  - 21
4099  - http://n.neurology.org/content/85/21/1869.short
4100  - http://n.neurology.org/content/85/21/1869.full
SO  - Neurology2015 Nov 24; 85
AB  - Objective: To estimate the ability of bedside information to risk stratify stroke in acute dizziness presentations.Methods: Surveillance methods were used to identify patients with acute dizziness and nystagmus or imbalance, excluding those with benign paroxysmal positional vertigo, medical causes, or moderate to severe neurologic deficits. Stroke was defined as acute infarction or intracerebral hemorrhage on a clinical or research MRI performed within 14 days of dizziness onset. Bedside information comprised history of stroke, the ABCD2 score (age, blood pressure, clinical features, duration, and diabetes), an ocular motor (OM)-based assessment (head impulse test, nystagmus pattern [central vs other], test of skew), and a general neurologic examination for other CNS features. Multivariable logistic regression was used to determine the association of the bedside information with stroke. Model calibration was assessed using low (<5%), intermediate (5% to <10%), and high (≥10%) predicted probability risk categories.Results: Acute stroke was identified in 29 of 272 patients (10.7%). Associations with stroke were as follows: ABCD2 score (continuous) (odds ratio [OR] 1.74; 95% confidence interval [CI] 1.20–2.51), any other CNS features (OR 2.54; 95% CI 1.06–6.08), OM assessment (OR 2.82; 95% CI 0.96–8.30), and prior stroke (OR 0.48; 95% CI 0.05–4.57). No stroke cases were in the model's low-risk probability category (0/86, 0%), whereas 9 were in the moderate-risk category (9/94, 9.6%) and 20 were in the high-risk category (20/92, 21.7%).Conclusion: In acute dizziness presentations, the combination of ABCD2 score, general neurologic examination, and a specialized OM examination has the capacity to risk-stratify acute stroke on MRI.ABCD2=age, blood pressure, clinical features, duration, diabetes; CI=confidence interval; HINTS=head impulse, nystagmus pattern, test of skew; HIT=head impulse test; ICH=intracerebral hemorrhage; OM=ocular motor; OR=odds ratio