PT  - JOURNAL ARTICLE
AU  - Marc Tardieu
AU  - Brenda Banwell
AU  - Jerry S. Wolinsky
AU  - Daniela Pohl
AU  - Lauren B. Krupp
TI  - Consensus definitions for pediatric MS and other demyelinating disorders in childhood
AID  - 10.1212/WNL.0000000000002877
DP  - 2016 Aug 30
TA  - Neurology
PG  - S8--S11
VI  - 87
IP  - 9 Supplement 2
4099  - http://n.neurology.org/content/87/9_Supplement_2/S8.short
4100  - http://n.neurology.org/content/87/9_Supplement_2/S8.full
SO  - Neurology2016 Aug 30; 87
AB  - In light of the published 2012 International Pediatric Multiple Sclerosis Group definitions for pediatric multiple sclerosis (MS) and related disorders and given that pediatric-onset MS is now formally included in the 2010 McDonald criteria for MS, we sought to review these criteria and summarize their application in children with acquired CNS demyelination. In addition, proposals are made for definitions of no evidence of disease activity and inadequate treatment response that are important because of new therapeutic options and trials.ADEM=acute disseminated encephalomyelitis; ARR=annualized relapse rate; CIS=clinically isolated syndrome; DIS=dissemination of inflammatory lesions in space; DIT=dissemination of inflammatory lesions in time; EDSS=Expanded Disability Status Scale; IPMSSG=International Pediatric Multiple Sclerosis Study Group; MOG=myelin oligodendroglial glycoprotein; MS=multiple sclerosis; NEDA=no evidence of disease activity; NMO=neuromyelitis optica; RIS=radiologically isolated syndrome