RT Journal Article
SR Electronic
T1 Consensus definitions for pediatric MS and other demyelinating disorders in childhood
JF Neurology
JO Neurology
FD Lippincott Williams & Wilkins
SP S8
OP S11
DO 10.1212/WNL.0000000000002877
VO 87
IS 9 Supplement 2
A1 Marc Tardieu
A1 Brenda Banwell
A1 Jerry S. Wolinsky
A1 Daniela Pohl
A1 Lauren B. Krupp
YR 2016
UL http://n.neurology.org/content/87/9_Supplement_2/S8.abstract
AB In light of the published 2012 International Pediatric Multiple Sclerosis Group definitions for pediatric multiple sclerosis (MS) and related disorders and given that pediatric-onset MS is now formally included in the 2010 McDonald criteria for MS, we sought to review these criteria and summarize their application in children with acquired CNS demyelination. In addition, proposals are made for definitions of no evidence of disease activity and inadequate treatment response that are important because of new therapeutic options and trials.ADEM=acute disseminated encephalomyelitis; ARR=annualized relapse rate; CIS=clinically isolated syndrome; DIS=dissemination of inflammatory lesions in space; DIT=dissemination of inflammatory lesions in time; EDSS=Expanded Disability Status Scale; IPMSSG=International Pediatric Multiple Sclerosis Study Group; MOG=myelin oligodendroglial glycoprotein; MS=multiple sclerosis; NEDA=no evidence of disease activity; NMO=neuromyelitis optica; RIS=radiologically isolated syndrome