PT  - JOURNAL ARTICLE
AU  - Wei Li
AU  - Shannon L. Risacher
AU  - Edgar Huang
AU  - Andrew J. Saykin
AU  - For the Alzheimer's Disease Neuroimaging Initiative
TI  - Type 2 diabetes mellitus is associated with brain atrophy and hypometabolism in the ADNI cohort
AID  - 10.1212/WNL.0000000000002950
DP  - 2016 Aug 09
TA  - Neurology
PG  - 595--600
VI  - 87
IP  - 6
4099  - http://n.neurology.org/content/87/6/595.short
4100  - http://n.neurology.org/content/87/6/595.full
SO  - Neurology2016 Aug 09; 87
AB  - Objective: We investigated type 2 diabetes mellitus (T2DM) as a risk factor for brain atrophy and glucose hypometabolism in older adults with or at risk of cognitive impairment.Methods: Participants with the T2DM were identified from the Alzheimer's Disease Neuroimaging Initiative (ADNI-1/GO/2 cohorts). Analysis of covariance models were used to compare participants with and without T2DM, controlling for potential confounding factors.Results: Whole brain volume and whole brain [18F]-fluorodeoxyglucose (FDG) uptake were significantly different as a function of T2DM status, independent of baseline clinical diagnosis. On post hoc analysis, a lower whole brain volume was seen in participants with both mild cognitive impairment (MCI) and T2DM (n = 76) compared with participants who had MCI but not T2DM (n = 747; p = 0.009). Similarly, mean FDG uptake in gray matter and white matter was lower in participants with both MCI and T2DM (n = 72) than in participants with MCI without T2DM (n = 719; p = 0.04). Subsequent regional analysis revealed that the decreased FDG uptake in participants with both MCI and T2DM was mainly manifested in 3 brain regions: frontal lobe, sensory motor cortex, and striatum.Conclusions: T2DM may accelerate cognition deterioration in patients with MCI by affecting glucose metabolism and brain volume.AD=Alzheimer disease; ADNI=Alzheimer's Disease Neuroimaging Initiative; CI=confidence interval; FDG=[18F]-fluorodeoxyglucose; HC=healthy control; MCI=mild cognitive impairment; SUVR=standardized uptake value ratio; SVD=small vessel disease; T2DM=type 2 diabetes mellitus