RT Journal Article SR Electronic T1 Acute plasma tau relates to prolonged return to play after concussion JF Neurology JO Neurology FD Lippincott Williams & Wilkins SP 595 OP 602 DO 10.1212/WNL.0000000000003587 VO 88 IS 6 A1 Gill, Jessica A1 Merchant-Borna, Kian A1 Jeromin, Andreas A1 Livingston, Whitney A1 Bazarian, Jeffrey YR 2017 UL http://n.neurology.org/content/88/6/595.abstract AB Objective: To determine whether tau changes after sport-related concussion (SRC) relate to return to play (RTP).Methods: Collegiate athletes underwent preseason plasma sampling and cognitive testing and were followed. After a SRC (n = 46), athletes and controls (n = 37) had sampling at 6 hours, and at 24 hours, 72 hours, and 7 days after SRC. A sample of 21 nonathlete controls were compared at baseline. SRC athletes were grouped by long (>10 days, n = 23) and short (≤10 days, n = 18) RTP. Total tau was measured using an ultrasensitive immunoassay.Results: Both SRC and athlete controls had significantly higher mean tau at baseline compared to nonathlete healthy controls (F101,3 = 19.644, p < 0.01). Compared to SRC athletes with short RTP, those with long RTP had higher tau concentrations overall, after controlling for sex (F39,1 = 3.59, p = 0.022), compared to long RTP athletes, at 6 (p < 0.01), 24 (p < 0.01), and 72 hours (p = 0.02). Receiver operator characteristic analyses showed that higher plasma tau 6 hours post-SRC was a significant predictor of RTP >10 days (area under the curve 0.81; 95% confidence interval 0.62–0.97, p = 0.01).Conclusions: Elevated plasma tau concentration within 6 hours following a SRC was related to having a prolonged RTP, suggesting that tau levels may help inform RTP.ANOVA=analysis of variance; AUC=area under the curve; BESS=Balance Error Scoring System; CI=confidence interval; CTE=chronic traumatic encephalopathy; ImPACT=Immediate Postconcussion Assessment and Cognitive Testing; mTBI=mild traumatic brain injury; NCAA=National Collegiate Athletic Association; RTP=return to play; SRC=sports-related concussions; TBI=traumatic brain injury