Table 3.

COMPASS and validity subscores in the three subject groups

DomainsMaximal possible score*Normal control (NML), n = 41Peripheral neuropathy (PN), n = 33Neurogenic autonomic failure (NAF), n = 39p Value
Mean% >0RangeMean% >0RangeMean% >0RangeNAF vs NMLNAF vs PN
* The lowest possible score is 0 for all domains.
† % >0: percent of people with a score greater than 0.
p values associated with Wilcoxon rank sum tests.
COMPASS = Composite Autonomic Symptom Scale; NS = not statistically significant, p > 0.05.
Orthostatic intolerance403.634.20–17.58.451.50–32.521.689.70–37.5<0.001<0.001
Secretomotor200.931.70–6.23.775.80–12.36.594.90–16.9<0.0010.002
Male sexual dysfunction300.621.70–8.65.875.00–12.99.571.40–19.3<0.001NS
Urinary200.831.70–41.345.50–82.969.20–14<0.0010.014
Gastroparesis100.522.00–5.70.736.40–4.32.459.00–10<0.0010.006
Diarrhea201.529.30–82.833.30–164.246.20–160.022NS
Constipation100.634.20–7.11.142.40–7.12.566.70–10<0.0010.018
Pupillomotor50.436.60–1.80.760.60–4.11.682.10–4.5<0.0010.006
Vasomotor100.47.30–6.32.339.40–7.52.238.50–8.1<0.001NS
Reflex syncope20000–00.26.10–4.00.923.10–4.00.0010.048
Sleep150.834.20–61.857.60–8.32.456.40–120.009NS
Validity scales
Understatement index101.346.30–52.057.60–8.32.664.10–100.05NS
Psychosomatic index100.02.40–1.80.19.10–2.70.617.90–6.30.02NS