Table 1.

Summary of clinical findings

Patient no./age at onset, y/sexInitial symptomsOnset of distal MGAChR Ab, nmol/LMax. RS decrementDistal weakness distribution
* Abnormal single fiber EMG of finger extensors, mean MCD 215 μsec.
† Abnormal single fiber EMG of finger extensors, mean MCD 62 μsec.
MG = myasthenia gravis; AChR = acetylcholine receptor; Ab = antibodies; RS = repetitive stimulation; ADM = abductor digiti minimi; FE = finger extensors; FA = finger abductors; TA = thumb abductors; SCM = sternocleidomastoid; WF = wrist flexors; WE = wrist extensors; FF = finger flexors; ADF = ankle dorsiflexors; TRAP = trapezires.
1/21/FOcularAfter 12 y22045% ADMFE 4, FA 4, TA 4
2/33/FHand weaknessAt onset8.717% SCMWF 3, WE 4, FF 3,
14% ADMFE 0, ADF 4
3/35/FOcularAfter 10 y10611% ADM*FA 3, FE 3
4/25/FHand weakness, dysphagia, dysarthiaAt onset16.2Not doneFA 4
5/30/MBulbar, generalized weaknessAfter 3 y2544% ADMFE 3
32% SCM
6/25/FLeft hand weaknessAt onset300% ADMFE, FA, TA 2–3,
30% TRAPADF 4
7/14/MOcularAfter 45 y9.866% ADMWE 3–4, FE 1–3,
TA 0–2, ADF 4
8/36/MOcularAfter 1 mo0.41“Positive” ADMFE, FF 4
9/29/MGeneralized weaknessAfter 14 y2.0329% ADMWF, FF 3
43% TRAP(forearm atrophy)