Results of the a priori pairwise comparisons between controls and different MS clinical phenotypes
| Controls vs CIS | Controls vs PPMS | CIS vs RRMS | RRMS vs BMS | RRMS vs SPMS | |
|---|---|---|---|---|---|
| See the text for statistical analysis. | |||||
| CIS = clinically isolated syndrome; PPMS = primary progressive MS; RRMS = relapsing-remitting MS; BMS = benign MS; SPMS = secondary progressive MS; NS = not significant; MTR = magnetization transfer ratio. | |||||
| Hypointense T1 lesion load | — | — | NS | NS | 0.0004 |
| Hyperintense T2 lesion load | — | — | 0.005 | NS | 0.001 |
| T1/T2 ratio | — | — | 0.004 | NS | 0.0002 |
| Average lesion MTR | — | — | 0.01 | NS | NS |
| Average brain MTR | NS | NS | 0.0009 | 0.05 | NS |
| MTR25 | NS | 0.04 | 0.0003 | 0.02 | 0.05 |
| MTR50 | NS | NS | 0.005 | NS | NS |
| MTR75 | NS | NS | 0.004 | NS | NS |
| Peak height | NS | 0.005 | 0.002 | 0.03 | NS |
| Peak position | NS | NS | 0.01 | NS | NS |