Table 1.

Characteristics of 222 patients with AD and 222 nondemented control subjects

CharacteristicAD patientsControl subjectsp Value*
* p Value based on the Wilcoxon signed rank tests for continuous variables and McNemar’s tests for proportions.
† When only the 31 case-control pairs discordant for estrogen use ≥ 6 months were considered, the median was 13.0 (10–16) for case patients and 13.5 (11–18) for control subjects.
‡ Number of years between menarche and menopause.
§ When only the 31 case-control pairs discordant for estrogen use ≥ 6 months were considered, the median was 2.0 (0–6) for case patients and 1.0 (0–5) for control subjects.
Education, y, median (range)12.0 (6–22)12.0 (6–20)0.02
Age at menarche, y, median (range)13.0 (10–18)13.0 (10–19)0.12
Age at menopause, y, median (range)50.0 (33–57)50.0 (28–60)0.59
Natural estrogen exposure, y, median (range)37.0 (23–44)36.0 (13–45)0.81
Live births, no., median (range)§1.0 (0–15)1.0 (0–10)0.19
Natural menopause, %90910.90
Endometrial cancer, %220.74
Breast cancer, %7120.05
Hypertension, %58560.70
Stroke, %22210.83