Table 3.

Association between AD and several putative risk factors (222 case patients and 222 control subjects) in all women with natural or medical menopause

Risk factorDiscordant pairs (case, control)Concordant pairs (case, control)Odds ratio (95% CI)p Value
+−−+++−−
* Discordant or concordant pairs not applicable for continuous variables.
† Test for linear trend assuming equal spacing of categories, p = 0.04.
‡ Test for linear trend assuming equal spacing of categories, p = 0.56.
CI = confidence interval.
Age at menarche, y (continuous)*0.85 (0.68–1.06)0.15
Age at menopause, y (continuous)*1.00 (0.95–1.05)0.92
Education, y (continuous)*0.93 (0.87–0.99)0.02
Estrogen (≥6 months vs otherwise)102111900.48 (0.22–1.01)0.05
Duration
<6 mo vs never172031500.85 (0.44–1.62)0.62
≥6 mo vs never81911500.42 (0.18–0.96)0.04
Total dose in mg (tertiles)
≤20 vs none5501771.34 (0.42–4.28)0.62
21–500 vs none6601750.77 (0.26–2.25)0.63
>500 vs none7901710.77 (0.28–2.06)0.60