Risk factor | Discordant pairs (case, control) | Concordant pairs (case, control) | Odds ratio (95% CI) | p Value | ||
---|---|---|---|---|---|---|

+− | −+ | ++ | −− | |||

* Discordant or concordant pairs not applicable for continuous variables. | ||||||

† Test for linear trend assuming equal spacing of categories, p = 0.04. | ||||||

‡ Test for linear trend assuming equal spacing of categories, p = 0.56. | ||||||

CI = confidence interval. | ||||||

Age at menarche, y (continuous)^{*} | — | — | — | — | 0.85 (0.68–1.06) | 0.15 |

Age at menopause, y (continuous)^{*} | — | — | — | — | 1.00 (0.95–1.05) | 0.92 |

Education, y (continuous)^{*} | — | — | — | — | 0.93 (0.87–0.99) | 0.02 |

Estrogen (≥6 months vs otherwise) | 10 | 21 | 1 | 190 | 0.48 (0.22–1.01) | 0.05 |

Duration | ||||||

<6 mo vs never | 17 | 20 | 3 | 150 | 0.85 (0.44–1.62) | 0.62 |

≥6 mo vs never | 8 | 19 | 1 | 150 | 0.42 (0.18–0.96)^{†} | 0.04 |

Total dose in mg (tertiles) | ||||||

≤20 vs none | 5 | 5 | 0 | 177 | 1.34 (0.42–4.28) | 0.62 |

21–500 vs none | 6 | 6 | 0 | 175 | 0.77 (0.26–2.25) | 0.63 |

>500 vs none | 7 | 9 | 0 | 171 | 0.77 (0.28–2.06)^{‡} | 0.60 |