Table 2.

Selected demographic variables, risk factors, and baseline MRI findings in individuals without, with minor, and with marked white matter hyperintensity progression

VariableProgressionp Value
Absent (n = 224)Minor (n = 27)Marked (n = 22)
* Kruskal–Wallis test.
† Mantel–Haenszel linear trend test.
‡ One-way analysis of variance.
Age, y, mean ± SD59.5 ± 6.162.2 ± 5.962.1 ± 5.50.02*
Sex, male, n (%)118 (52.7)10 (37.0)14 (63.6)0.83
Hypertension, n (%)84 (37.5)10 (37.0)13 (59.1)0.09
Systolic blood pressure, mm Hg, mean ± SD137.9 ± 18.1142.6 ± 20.1146.8 ± 19.00.06
Diastolic blood pressure, mm Hg, mean ± SD84.6 ± 8.086.2 ± 8.889.3 ± 10.30.03
Fibrinogen, mg/dL, mean ± SD286.8 ± 65.4300.0 ± 59.2303.5 ± 49.90.03*
Baseline MRI findings
Grade, n (%)
087 (38.8)9 (33.3)1 (4.5)
1117 (52.2)14 (51.9)11 (50.0)
216 (7.1)2 (7.4)7 (31.8)
34 (1.8)2 (7.4)3 (13.6)<0.00001
Number, n (%)
087 (38.8)9 (33.3)1 (4.5)
1 to 477 (34.4)8 (29.6)5 (22.7)
5 to 927 (12.1)4 (14.8)5 (22.7)
>933 (14.7)6 (22.2)11 (50.0)0.00001