Variable | Placebo, n = 43 | Lenercept, mg | p Value | ||
---|---|---|---|---|---|

10, n = 44 | 50, n = 40 | 100, n = 40 | |||

* Analysis of variance of Ln(1 + x). | |||||

† Kruskal-Wallis test. | |||||

Newly active lesions, mean Median (range) | 8.9 4.0 (0–92) | 8.2 3.0 (0–55) | 15.5 5.5 (0–124) | 12.0 4.5 (0–102) | 0.43^{*} |

Persistently active lesions, mean Median (range) | 6.2 1.0 (0–100) | 3.3 1.0 (0–49) | 9.6 1.0 (0–128) | 3.3 1.0 (0–24) | 0.36^{*} |

Percent of active scans,^{†} mean Median (range) | 45.6 50 (0–100) | 40.6 33 (0–100) | 51.6 50 (0–100) | 49.2 55 (0–100) | 0.58^{†} |

Percent change in burden of disease,^{†} mean Median (range) | 6.0 −2.2 (−28.8–280.9) | 9.9 0.0 (−30.5–251.0) | 4.3 1.4 (−35.2–62.8) | 4.9 −0.2 (−36.0–81.4) | 0.74^{†} |