Exacerbations | Placebo, n = 43 | Lenercept, mg | p Value | ||
---|---|---|---|---|---|

10, n = 44 | 50, n = 40 | 100, n = 40 | |||

* Chi-square tests: global. | |||||

† Kruskal-Wallis test. | |||||

‡ Kaplan-Meier (KM) (means and medians are estimated from the KM curves). | |||||

Patients with at least one exacerbation through week 24, n | 15 | 21 | 28 | 27 | 0.003^{*} |

Patients with at least one exacerbation through week 48, n | 22 | 26 | 32 | 32 | 0.007^{†} |

Exacerbations with onset ≤ week 24 | 22 | 28 | 37 | 33 | |

Duration (days) of these exacerbations, mean Median (range) | 28.3 28 (1–91) | 38.6 31 (6–189) | 41.6 31 (6–201) | 42.0 25 (4–261) | 0.62^{‡} |

Annualized exacerbation rate | 0.98 | 1.00 | 1.64 | 1.47 |