Table 5.

Change in the NRS and the EDSS during the lenercept MS trial

Rating scalePlacebo, n = 43Lenercept, mgp Value
10, n = 4450, n = 40100, n = 40
* Chi-square.
† Kruskal-Wallis test.
NRS = Neurological Rating Scale; EDSS = Expanded Disability Status Scale.
NRS, weeks 1–48
No change or improved141399
Mild deterioration211814180.37*
Moderate deterioration31087
Severe deterioration5396
EDSS, weeks 1–24, n43444040
Mean change (range)−0.131 (−2.0 to 2.0)−0.295 (−3.0 to 5.5)−0.05 (−2.0 to 2.0)−0.075 (112.0 to 4.0)0.24
EDSS, weeks 1–48
Mean change (range)0.014 (−1.0 to 2.0)−0.024 (−3.0 to 5.5)−0.026 (−2.0 to 2.0)0.171 (−2.0 to 4.0)0.71