Table 2.

Baseline electrophysiologic and vibration perception threshold data by treatment group for randomized subjects with evaluable baseline determinations (and completers*)

Neurophysiologic measuresPlacebo, n = 45150 mg bid, n = 46300 mg bid, n = 47600 mg bid, n = 49
* Italicized rows refer to completers only; number of electrophysiologic completers per treatment group is given in table 5.
NCV = nerve conduction velocity; SNCV = sensory nerve conduction velocity; MNCV = motor nerve conduction velocity; SNAP = sensory nerve action potential.
SNCV median, m/sec55.2 ± 0.855.3 ± 0.853.8 ± 0.655.0 ± 0.7
SNCV median, m/sec54.9 ± 0.855.0 ± 0.953.7 ± 0.655.2 ± 0.8
SNCV sural, m/sec43.0 ± 0.843.3 ± 0.840.6 ± 0.842.2 ± 0.8
SNCV sural, m/sec42.8 ± 0.942.7 ± 0.940.6 ± 0.941.8 ± 0.9
MNCV peroneal, m/sec40.8 ± 0.940.5 ± 0.839.8 ± 0.741.1 ± 0.6
MNCV peroneal, m/sec40.7 ± 1.040.2 ± 1.039.7 ± 0.741.0 ± 0.7
NCV rank score0.53 ± 0.040.52 ± 0.040.44 ± 0.030.51 ± 0.03
NCV rank score0.52 ± 0.040.50 ± 0.040.43 ± 0.030.51 ± 0.04
SNAP—amplitude median, μV17.3 ± 1.617.9 ± 1.916.6 ± 1.516.3 ± 1.4
SNAP—amplitude sural, μV8.02 ± 0.787.23 ± 0.826.23 ± 0.676.51 ± 0.46
M—amplitude peroneal, mV4.34 ± 0.423.88 ± 0.354.29 ± 0.353.94 ± 0.30
Vibration perception threshold toe, μm9.1 ± 1.313.2 ± 2.111.9 ± 2.313.5 ± 2.4
(n = 48)(n = 47)(n = 51)(n = 51)