Table 3.

Baseline light microscopic morphometric data by treatment group for randomized subjects with readable baseline biopsies (and completers*)

Morphometric measuresPlacebo, n = 43150 mg bid, n = 43300 mg bid, n = 48600 mg bid, n = 40
* Italicized rows refer to baseline values from completers only; number of biopsy completers per treatment group is given in table 6.
† Measured only in placebo and 300 mg bid groups.
MNFD = myelinated nerve fiber density; CVMNFD = coefficient of variation of myelinated nerve fiber density.
MNFD, n/mm2, total4,528 ± 2654,183 ± 2853,840 ± 2304,001 ± 254
MNFD, n/mm2, total4,381 ± 3473,747 ± 3413,748 ± 2533,857 ± 317
MNFD, n/mm2, ≤5.0 μm2,309 ± 1482,183 ± 1562,028 ± 1382,101 ± 147
MNFD, n/mm2, ≤5.0 μm2,278 ± 2041,984 ± 1962,003 ± 1551,997 ± 179
Endoneurial area, μm2 × 103913 ± 66941 ± 47
Fascicular area, μm2 × 103204 ± 9229 ± 12237 ± 13215 ± 11
Fiber occupancy, %17.5 ± 1.215.5 ± 1.214.7 ± 1.114.6 ± 1.0
Mean fiber area, μm239.1 ± 1.137.2 ± 1.438.1 ± 1.636.5 ± 1.1
Axon/myelin ratio0.52 ± 0.010.53 ± 0.010.53 ± 0.010.51 ± 0.01
CVMNFD, n/mm232.0 ± 1.333.3 ± 1.536.5 ± 1.633.9 ± 1.4