Table 6.

Change in sural sensory nerve light microscopic morphometry during treatment, mean ± SD

Δ Morphometric measuresPlacebo, n = 26150 mg bid, n = 26300 mg bid, n = 34600 mg bid, n = 35p Value*
* Adjusted for Williams’ test.
† Measured only in placebo and 300-mg bid treatment groups.
MNFD = myelinated nerve fiber density; CVMNFD = coefficient of variation of myelinated nerve fiber density.
Δ MNFD, n/mm2
Diameter 5–≤8.0 μm−5 ± 47−54 ± 5322 ± 5733 ± 790.95
Diameter 8–≤11.0 μm−35 ± 68−107 ± 6820 ± 65−75 ± 840.65
Diameter >11.0 μm−7 ± 7730 ± 53−22 ± 45−20 ± 531.0
Δ Endoneurial area, μm2 × 103−6 ± 7051 ± 840.76
Δ Fascicular area, μm2 × 10319.5 ± 19.0−1.4 ± 16.49.6 ± 24.5−6.2 ± 16.30.58
Δ Fiber occupancy, %−0.7 ± 1.2−0.5 ± 0.8−0.1 ± 0.8−0.5 ± 1.30.42
Δ Mean fiber area, μm21.1 ± 1.70.4 ± 1.8−1.3 ± 1.9−2.4 ± 1.70.08
Δ Axon/myelin ratio−0.01 ± 0.01−0.01 ± 0.01−0.02 ± 0.010.01 ± 0.010.36
Δ CVMNFD, n/mm22.2 ± 1.22.9 ± 1.70.2 ± 1.61.9 ± 1.70.37