Table 1.

Distribution of genotypes of tau gene polymorphisms

SampleTau genotypeTau allele
A0/A0A0/A1A0/A2A0/A3A1/A1A1/A2A1/A3A2/A2A2/A3A3/A3A0A1A2A3
BS indicates the DNA was obtained from brain. All data are presented as number (%) of individuals. In some cases, the p values compared with controls were calculated. Differences were considered significant when p < 0.05.
PSP = progressive supranuclear palsy.
Controls, n = 79 (%)37 (46.8)02 (2.5)33 (41.7)01 (1.2)1 (1.2)1 (1.2)04 (5.4)109 (69)2 (1.3)5 (3.2)42 (26)
PSP, n = 16 (%)15 (93.8)1 (6.3)0000000031 (97)1 (3)00
p < 0.001p < 0.002
Asymptomatic PSP relatives,21 (75.0)03 (10.7)3 (10.7)10000048 (85.7)2 (3.6)3 (5.35)3 (5.35)
on = 28 (%)p < 0.018p < 0.02
PD, n = 18 (%)13 (72.2)1 (5.5)02 (11.3)1 (5.5)00001 (5.5)29 (80.5)3 (8.3)04 (11.2)
p < 0.09p < 0.23
BS-controls (n = 10)4 (40)1 (10)04 (40)000001 (10)13 (65)1 (5)06 (30)
BS-PSP (n = 7)6 (85.7)1 (14.3)0000000013 (92.8)1 (7.2)00
BS-AD (n = 9)3 (33.3)005 (55.5)000001 (11.1)11 (61.1)007 (38.9)
BS-other neurologic disorders3 (60)001 (20)000001 (20)7 (70)003 (30)
(n = 5)