Table 2.

Genotype frequencies of TNFA -376 and HLA-DRB1*1501 in controls and MS patients

TNFA-376 genotypeHLA-DRB1 genotypeMS, n = 238, n (%)Controls, n = 324, n (%)MS versus controls
pOR (CI)*
Stratified analysis: aDRB1*1501 positive: OR (CI) = 3.67 (1.06–13.90), p < 0.05, when compared with DRB1*1501 positive controls; bDRB1*1501 negative: OR (CI) = 1.67 (0.88–3.16), p = 0.09, when compared with DRB1*1501 negative controls.
* Odds ratio (95% confidence limits).
NS = not significant.
All*1501 Positive76 (31.9)59 (18.2)<0.0012.11 (1.40–3.18)
AA or AG*1501 Positive16a (6.7)4 (1.2)<0.0015.77 (1.78–20.68)
GG*1501 Positive60 (25.2)55 (17.0)<0.051.65 (1.07–2.54)
AA or AG*1501 Negative24b (10.1)25 (7.7)NS1.34 (0.72–2.51)
GG*1501 Negative138 (58.0)240 (74.1)<0.0010.48 (0.33–0.70)