Table 2.

Association between clinical characteristics and paraneoplastic encephalomyelitis (PEM) outcome in 51 patients with Hu-Ab

CharacteristicPEM evolution, n (%)p Value
Better/stable, n = 36Worse, n = 15
Hu-Ab = anti-Hu antibodies; SCLC = small cell lung cancer; SSN = sensory neuropathy
Median age, y (range)62 (37–79)59 (47–75)0.51
Rankin score
0–328 (78.8)8 (53.3)0.08
4–58 (22.2)7 (46.7)
Neurologic syndrome
SSN24 (66.7)10 (66.7)1
Other12 (33.3)5 (33.3)
Median delay (mo) in tumor diagnosis (range)5 (0–32)4 (1–20)0.67
Tumor type
SCLC30 (83.3)12 (80)0.53
Other6 (17.7)3 (20)
Tumor response
Complete23 (63.9)3 (20)0.004
Other13 (36.1)12 (80)
Immunotherapy
Yes17 (47.2)8 (53.3)0.69
No19 (52.7)7 (46.7)