Table 4.

Clinical characteristics of small-cell lung cancer (SCLC) patients with paraneoplastic encephalomyelitis (PEM) and those without PEM and no Hu-Ab

CharacteristicPEM, positive for Hu-Ab, n = 27No PEM,* negative for Hu-Ab, n = 27
* Values are n (%). SCLC patients without PEM included in a previous study (see text).
† “Good” performance status was Rankin 0–3 for PEM patients, Eastern Cooperative Oncology Group (ECOG) 0–2 for patients without PEM; “Bad” performance status was Rankin 4–5 for PEM patients, ECOG 3–4 for patients without PEM.
Hu-Ab = anti-Hu antibodies; RT = radiotherapy.
Age, y
<6011 (40.7)11 (40.7)
≥6016 (59.3)16 (59.3)
Male sex21 (77.8)23 (85.2)
Performance status†
“Good”25 (92.6)25 (92.6)
“Bad”2 (7.4)2 (7.4)
Staging procedures
CT scan of the chest27 (100)27 (100)
CT scan of the abdomen27 (100)26 (96.3)
CT scan of the head25 (92.6)17 (63.1)
Bone scan21 (77.8)25 (92.6)
Bone marrow biopsy6 (22.2)9 (33.3)
Extent of disease
Limited21 (77.8)21 (77.8)
Extensive6 (22.2)6 (22.2)
Metastatic sites
Adrenal4 (66.6)4 (66.6)
Liver1 (16.7)1 (16.7)
Multiple1 (16.7)1 (16.7)
Treatment regimen
Chemotherapy13 (48.1)13 (48.1)
Chemotherapy + thoracic RT14 (51.9)14 (51.9)
Treatment response
Complete15 (55.6)13 (48.1)
Partial6 (22.2)9 (33.3)
Stable/progression6 (22.2)5 (18.3)
Median survival, mo1314
Probability of survival, %
12 mo5559
30 mo3015