Neuropathologic findings of patients with cortical–basal ganglionic degeneration (CBGD)
| Patient no. | Cortical neuronal loss and gliosis | Subcortical neuronal loss and gliosis* | Swollen neurons | Tau immunodeposits in frontal cortex | ||||
|---|---|---|---|---|---|---|---|---|
| Striatum | Globus pallidus | Substantia nigra | Neurofibrillary tangles† | Neuropil threads and glial inclusions‡ | Astrocytic plaques | |||
| * 0 = absent, 1 = mild, 2 = moderate, 3 = severe. | ||||||||
| † 0 = absent, 1 = no more than one per 250× field, 2 = at least one field with two to five, 3 = at least one field with more than five. | ||||||||
| ‡ 0 = absent, 1 = low density, 2 = moderate density, 3 = high density. | ||||||||
| N/A = Not available. | ||||||||
| 1 | Severe frontal | 0 | 2 | 3 | Yes | 2 | 3 | Yes |
| 2 | Severe frontal | 1 | 1 | 3 | Yes | 2 | 2 | Yes |
| 3 | Moderate frontal | 1 | 1 | 2 | Yes | 1 | 3 | Yes |
| 4 | Severe frontal | 2 | 3 | 3 | Yes | 1 | 3 | Yes |
| 5 | Mild frontal | 1 | N/A | 3 | Yes | 1 | 3 | Yes |
| 6 | Severe frontal | 2 | 2 | 3 | Yes | 3 | 3 | Yes |
| 7 | Moderate frontal | 1 | 0 | 3 | Yes | 1 | 2 | Yes |
| 8 | Moderate parietal, mild frontal | 2 | 2 | 3 | Yes | 1 | 3 | Yes |
| 9 | Moderate frontal | 1 | 1 | 2 | Yes | 1 | 2 | Yes |
| 10 | Severe frontal | 1 | 3 | 3 | Yes | 3 | 3 | Yes |
| 11 | Mild frontal, temporal and parietal | 2 | 2 | 3 | Yes | 1 | 3 | Yes |
| 12 | Moderate frontal | 2 | 3 | 3 | Yes | 2 | 3 | Yes |
| 13 | Mild frontal | 1 | 1 | 3 | Yes | 2 | 3 | Yes |